NAGK

From Wikipedia, the free encyclopedia

N-acetylglucosamine kinase

PDB rendering based on 2ch5.

Available structures: 2ch5, 2ch6

Identifiers

Symbol(s)

NAGK; GNK; HSA242910

External IDs

OMIM: 606828 MGI: 1860418 HomoloGene: 9720

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • N-acylmannosamine kinase activity • kinase activity • transferase activity • N-acetylglucosamine kinase activity
Cellular Component:	• soluble fraction
Biological Process:	• N-acetylglucosamine metabolic process • N-acetylmannosamine metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017567 (mRNA)
NP_060037 (protein)

NM_019542 (mRNA)
NP_062415 (protein)

Location

Chr 2: 71.15 - 71.16 Mb

Chr 6: 83.76 - 83.77 Mb

Pubmed search

[1]

[2]

N-acetylglucosamine kinase, also known as NAGK, is a human gene.^[1]

N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NAGK N-acetylglucosamine kinase.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Weidanz JA, Campbell P, Moore D, et al. (1997). "N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum.". Br. J. Haematol. 95 (4): 645–53. PMID 8982040.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lowes W, Walker M, Alberti KG, Agius L (1998). "Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.". Biochim. Biophys. Acta 1379 (1): 134–42. PMID 9468341.
Hinderlich S, Berger M, Schwarzkopf M, et al. (2000). "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase.". Eur. J. Biochem. 267 (11): 3301–8. PMID 10824116.
Ligos JM, de Lera TL, Hinderlich S, et al. (2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling.". J. Biol. Chem. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.
Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets.". Proteomics 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Sparks SE, Ciccone C, Lalor M, et al. (2006). "Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy.". Glycobiology 15 (11): 1102–10. doi:10.1093/glycob/cwi100. PMID 15987957.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Weihofen WA, Berger M, Chen H, et al. (2007). "Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation.". J. Mol. Biol. 364 (3): 388–99. doi:10.1016/j.jmb.2006.08.085. PMID 17010375.