NADSYN1

From Wikipedia, the free encyclopedia

NAD synthetase 1

Identifiers

NADSYN1; FLJ10631; FLJ36703; FLJ40627

External IDs

OMIM: 608285 MGI: 1926164 HomoloGene: 6098

Gene ontology
Molecular Function:	• nucleotide binding • NAD+ synthase (glutamine-hydrolyzing) activity • ATP binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • ligase activity
Biological Process:	• nitrogen compound metabolic process • NAD biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018161 (mRNA)
NP_060631 (protein)

XM_993970 (mRNA)
XP_999064 (protein)

Location

Chr 11: 70.84 - 70.89 Mb

Chr 7: 143.6 - 143.63 Mb

Pubmed search

[1]

[2]

NAD synthetase 1, also known as NADSYN1, is a human gene.^[1]

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NADSYN1 NAD synthetase 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hara N, Yamada K, Terashima M, et al. (2003). "Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.". J. Biol. Chem. 278 (13): 10914–21. doi:10.1074/jbc.M209203200. PMID 12547821.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.