NAB2

From Wikipedia, the free encyclopedia

NGFI-A binding protein 2 (EGR1 binding protein 2)

Identifiers

NAB2; MADER; MGC75085

External IDs

OMIM: 602381 MGI: 107563 HomoloGene: 4353

Gene ontology
Molecular Function:	• transcription corepressor activity • transcription repressor activity
Cellular Component:	• nucleus
Biological Process:	• endochondral ossification • regulation of transcription, DNA-dependent • nervous system development • cell proliferation • Schwann cell differentiation • negative regulation of transcription • myelination • regulation of epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005967 (mRNA)
NP_005958 (protein)

NM_008668 (mRNA)
NP_032694 (protein)

Location

Chr 12: 55.77 - 55.78 Mb

Chr 10: 127.06 - 127.07 Mb

Pubmed search

[1]

[2]

NGFI-A binding protein 2 (EGR1 binding protein 2), also known as NAB2, is a human gene.^[1]

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2).

[edit] Further reading

Kirsch KH, Korradi Y, Johnson JP (1996). "Mader: a novel nuclear protein over expressed in human melanomas.". Oncogene 12 (5): 963-71. PMID 8649813.
Svaren J, Sevetson BR, Apel ED, et al. (1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.". Mol. Cell. Biol. 16 (7): 3545-53. PMID 8668170.
Svaren J, Apel ED, Simburger KS, et al. (1997). "The Nab2 and Stat6 genes share a common transcription termination region.". Genomics 41 (1): 33-9. doi:10.1006/geno.1997.4609. PMID 9126479.
Qu Z, Wolfraim LA, Svaren J, et al. (1998). "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells.". J. Cell Biol. 142 (4): 1075-82. PMID 9722618.
Svaren J, Sevetson BR, Golda T, et al. (1998). "Novel mutants of NAB corepressors enhance activation by Egr transactivators.". EMBO J. 17 (20): 6010-9. doi:10.1093/emboj/17.20.6010. PMID 9774344.
Abdulkadir SA, Qu Z, Garabedian E, et al. (2001). "Impaired prostate tumorigenesis in Egr1-deficient mice.". Nat. Med. 7 (1): 101-7. doi:10.1038/83231. PMID 11135623.
Abdulkadir SA, Carbone JM, Naughton CK, et al. (2001). "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma.". Hum. Pathol. 32 (9): 935-9. doi:10.1053/hupa.2001.27102. PMID 11567222.
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies.". Neurogenetics 4 (1): 37-41. PMID 12030330.
Lucerna M, Mechtcheriakova D, Kadl A, et al. (2003). "NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells.". J. Biol. Chem. 278 (13): 11433-40. doi:10.1074/jbc.M204937200. PMID 12427750.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kumbrink J, Gerlinger M, Johnson JP (2006). "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.". J. Biol. Chem. 280 (52): 42785-93. doi:10.1074/jbc.M511079200. PMID 16260776.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Srinivasan R, Mager GM, Ward RM, et al. (2006). "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.". J. Biol. Chem. 281 (22): 15129-37. doi:10.1074/jbc.M600775200. PMID 16574654.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.