N-sulfoglucosamine sulfohydrolase

From Wikipedia, the free encyclopedia

In enzymology, a N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1) is an enzyme that catalyzes the chemical reaction

N-sulfo-D-glucosamine + H₂O D-glucosamine + sulfate

Thus, the two substrates of this enzyme are N-sulfo-D-glucosamine and H₂O, whereas its two products are D-glucosamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is N-sulfo-D-glucosamine sulfohydrolase. Other names in common use include sulfoglucosamine sulfamidase, heparin sulfamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate, and sulphohydrolase). This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.

[edit] References

• IUBMB entry for 3.10.1.1
• BRENDA references for 3.10.1.1 (Recommended.)
• PubMed references for 3.10.1.1
• PubMed Central references for 3.10.1.1
• Google Scholar references for 3.10.1.1
• Dietrich CP (1969). "Enzymic degradation of heparin. A sulphamidase and a sulphoesterase from Flavobacterium heparinum". Biochem. J. 111: 91–5. PMID 5775690. 
• Mahuran D, Clements P, Hopwood J (1983). "A rapid four column purification of 2-deoxy-D-glucoside-2-sulphamate sulphohydrolase from human liver". Biochim. Biophys. Acta. 757: 359–65. PMID 6849981. 

[edit] External links

The CAS registry number for this enzyme class is 37289-41-1.

• IUBMB entry for 3.10.1.1

• KEGG entry for 3.10.1.1

• BRENDA entry for 3.10.1.1

• NiceZyme view of 3.10.1.1

• EC2PDB: PDB structures for 3.10.1.1

• PRIAM entry for 3.10.1.1

• PUMA2 entry for 3.10.1.1

• IntEnz: Integrated Enzyme entry for 3.10.1.1

• MetaCyc entry for 3.10.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016250: N-sulfoglucosamine sulfohydrolase

• AMIGO entry for GO code 0016250: N-sulfoglucosamine sulfohydrolase