N-methyl-2-oxoglutaramate hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a N-methyl-2-oxoglutaramate hydrolase (EC 3.5.1.36) is an enzyme that catalyzes the chemical reaction

N-methyl-2-oxoglutaramate + H₂O 2-oxoglutarate + methylamine

Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H₂O, whereas its two products are 2-oxoglutarate and methylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.

[edit] References

• IUBMB entry for 3.5.1.36
• BRENDA references for 3.5.1.36 (Recommended.)
• PubMed references for 3.5.1.36
• PubMed Central references for 3.5.1.36
• Google Scholar references for 3.5.1.36
• Hersh LB (1970). "5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action". J. Biol. Chem. 245: 3526–35. PMID 5470822. 
• Hersh LB, Tsai L, Stadtman ER (1969). "The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid". J. Biol. Chem. 244: 4677–83. PMID 5808511. 

[edit] External links

The CAS registry number for this enzyme class is 9073-53-4.

• IUBMB entry for 3.5.1.36

• KEGG entry for 3.5.1.36

• BRENDA entry for 3.5.1.36

• NiceZyme view of 3.5.1.36

• EC2PDB: PDB structures for 3.5.1.36

• PRIAM entry for 3.5.1.36

• PUMA2 entry for 3.5.1.36

• IntEnz: Integrated Enzyme entry for 3.5.1.36

• MetaCyc entry for 3.5.1.36

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050130: N-methyl-2-oxoglutaramate hydrolase

• AMIGO entry for GO code 0050130: N-methyl-2-oxoglutaramate hydrolase