N-isopropylammelide isopropylaminohydrolase

From Wikipedia, the free encyclopedia

In enzymology, a N-isopropylammelide isopropylaminohydrolase (EC 3.5.99.4) is an enzyme that catalyzes the chemical reaction

N-isopropylammelide + H₂O cyanuric acid + isopropylamine

Thus, the two substrates of this enzyme are N-isopropylammelide and H₂O, whereas its two products are cyanuric acid and isopropylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is N-isopropylammelide isopropylaminohydrolase. This enzyme is also called AtzC. This enzyme participates in atrazine degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QT3.

[edit] References

• IUBMB entry for 3.5.99.4
• BRENDA references for 3.5.99.4 (Recommended.)
• PubMed references for 3.5.99.4
• PubMed Central references for 3.5.99.4
• Google Scholar references for 3.5.99.4
• Sadowsky MJ, Tong Z, de Souza M, Wackett LP (1998). "AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes". J. Bacteriol. 180: 152–8. PMID 9422605. 

[edit] External links

• IUBMB entry for 3.5.99.4

• KEGG entry for 3.5.99.4

• BRENDA entry for 3.5.99.4

• NiceZyme view of 3.5.99.4

• EC2PDB: PDB structures for 3.5.99.4

• PRIAM entry for 3.5.99.4

• PUMA2 entry for 3.5.99.4

• IntEnz: Integrated Enzyme entry for 3.5.99.4

• MetaCyc entry for 3.5.99.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018764: N-isopropylammelide isopropylaminohydrolase

• AMIGO entry for GO code 0018764: N-isopropylammelide isopropylaminohydrolase