N-carbamoylsarcosine amidase

From Wikipedia, the free encyclopedia

In enzymology, a N-carbamoylsarcosine amidase (EC 3.5.1.59) is an enzyme that catalyzes the chemical reaction

N-carbamoylsarcosine + H₂O sarcosine + CO₂ + NH₃

Thus, the two substrates of this enzyme are N-carbamoylsarcosine and H₂O, whereas its 3 products are sarcosine, CO₂, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoylsarcosine amidohydrolase. This enzyme is also called carbamoylsarcosine amidase. This enzyme participates in arginine and proline metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1NBA.

[edit] References

• IUBMB entry for 3.5.1.59
• BRENDA references for 3.5.1.59 (Recommended.)
• PubMed references for 3.5.1.59
• PubMed Central references for 3.5.1.59
• Google Scholar references for 3.5.1.59
• Deeg R, Roeder A, Siedel J, Gauhl H and Ziegenhorn J (1984). "Process and reagent for the determination of N-carbamoylsarcosine with the use of a new enzyme". Chem. Abstr. 101: 18751. 

[edit] External links

The CAS registry number for this enzyme class is 92767-52-7.

• IUBMB entry for 3.5.1.59

• KEGG entry for 3.5.1.59

• BRENDA entry for 3.5.1.59

• NiceZyme view of 3.5.1.59

• EC2PDB: PDB structures for 3.5.1.59

• PRIAM entry for 3.5.1.59

• PUMA2 entry for 3.5.1.59

• IntEnz: Integrated Enzyme entry for 3.5.1.59

• MetaCyc entry for 3.5.1.59

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050127: N-carbamoylsarcosine amidase

• AMIGO entry for GO code 0050127: N-carbamoylsarcosine amidase