N-acylmannosamine kinase

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In enzymology, a N-acylmannosamine kinase (EC 2.7.1.60) is an enzyme that catalyzes the chemical reaction

ATP + N-acyl-D-mannosamine ADP + N-acyl-D-mannosamine 6-phosphate

Thus, the two substrates of this enzyme are ATP and N-acyl-D-mannosamine, whereas its two products are ADP and N-acyl-D-mannosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acyl-D-mannosamine 6-phosphotransferase. Other names in common use include acylmannosamine kinase (phosphorylating), acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, N-acyl-D-mannosamine kinase, N-acetylmannosamine kinase, and ATP:N-acetylmannosamine 6-phosphotransferase. This enzyme participates in aminosugars metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AA4.

[edit] References

• IUBMB entry for 2.7.1.60
• BRENDA references for 2.7.1.60 (Recommended.)
• PubMed references for 2.7.1.60
• PubMed Central references for 2.7.1.60
• Google Scholar references for 2.7.1.60
• Banerjee S, Ghosh S (1969). "Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium". Eur. J. Biochem. 8: 200–6. PMID 4889177. 
• GHOSH S, ROSEMAN S (1961). "Enzymatic phosphorylation of N-acetyl-D-mannosamine". Proc. Natl. Acad. Sci. U. S. A. 47: 955–8. PMID 13704957. 
• Kundig W, Ghosh S, Roseman S (1966). "The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver". J. Biol. Chem. 241: 5619–26. PMID 5928201. 

[edit] External links

The CAS registry number for this enzyme class is 9027-53-6.

• IUBMB entry for 2.7.1.60

• KEGG entry for 2.7.1.60

• BRENDA entry for 2.7.1.60

• NiceZyme view of 2.7.1.60

• EC2PDB: PDB structures for 2.7.1.60

• PRIAM entry for 2.7.1.60

• PUMA2 entry for 2.7.1.60

• IntEnz: Integrated Enzyme entry for 2.7.1.60

• MetaCyc entry for 2.7.1.60

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0009384: N-acylmannosamine kinase

• AMIGO entry for GO code 0009384: N-acylmannosamine kinase