N-acetylneuraminate 4-O-acetyltransferase

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In enzymology, a N-acetylneuraminate 4-O-acetyltransferase (EC 2.3.1.44) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + N-acetylneuraminate $\rightleftharpoons$ CoA + N-acetyl-4-O-acetylneuraminate

Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its two products are CoA and N-acetyl-4-O-acetylneuraminate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase. This enzyme is also called sialate O-acetyltransferase.

[edit] References

IUBMB entry for 2.3.1.44
BRENDA references for 2.3.1.44 (Recommended.)
PubMed references for 2.3.1.44
PubMed Central references for 2.3.1.44
Google Scholar references for 2.3.1.44
Schauer R (1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]". Hoppe. Seylers. Z. Physiol. Chem. 351: 595–602. PMID 5446640.
Schauer R (1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]". Hoppe. Seylers. Z. Physiol. Chem. 351: 749–58. PMID 5425947.