MZF1

From Wikipedia, the free encyclopedia

Myeloid zinc finger 1

PDB rendering based on 2fi2.

Available structures: 2fi2

Identifiers

Symbol(s)

MZF1; MZF-1; MZF1B; ZNF42; ZSCAN6; Zfp98

External IDs

OMIM: 194550 MGI: 107457 HomoloGene: 9633

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003422 (mRNA)
NP_003413 (protein)

NM_145819 (mRNA)
NP_665818 (protein)

Location

Chr 19: 63.77 - 63.78 Mb

Chr 7: 11.94 - 11.95 Mb

Pubmed search

[1]

[2]

Myeloid zinc finger 1, also known as MZF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MZF1 myeloid zinc finger 1.

[edit] Further reading

Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.". J. Exp. Med. 174 (5): 1097–101. PMID 1719120.
Hromas R, Collins SJ, Hickstein D, et al. (1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.". J. Biol. Chem. 266 (22): 14183–7. PMID 1860835.
Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations.". J. Biol. Chem. 275 (17): 12857–67. PMID 10777584.
Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein.". Gene 254 (1-2): 105–18. PMID 10974541.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMID 15453830.
Kang NY, Park YD, Choi HJ, et al. (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene.". Mol. Cells 18 (2): 157–62. PMID 15528990.
Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts.". Exp. Cell Res. 302 (1): 129–42. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
Inoue M, Takahashi K, Niide O, et al. (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis.". FEBS Lett. 579 (3): 604–8. doi:10.1016/j.febslet.2004.12.030. PMID 15670815.
Hsieh YH, Wu TT, Tsai JH, et al. (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells.". Biochem. Biophys. Res. Commun. 339 (1): 217–25. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
Peterson FC, Hayes PL, Waltner JK, et al. (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1.". J. Mol. Biol. 363 (1): 137–47. doi:10.1016/j.jmb.2006.07.063. PMID 16950398.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.