MYOZ2

From Wikipedia, the free encyclopedia

Myozenin 2

Identifiers

MYOZ2; CS-1; C4orf5

External IDs

OMIM: 605602 MGI: 1913063 HomoloGene: 9583

Gene ontology
Molecular Function:	• structural molecule activity • protein binding • protein phosphatase 2B binding
Cellular Component:	• actin cytoskeleton • Z disc
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016599 (mRNA)
NP_057683 (protein)

NM_021503 (mRNA)
NP_067478 (protein)

Location

Chr 4: 120.28 - 120.33 Mb

Chr 3: 123 - 123.03 Mb

Pubmed search

[1]

[2]

Myozenin 2, also known as MYOZ2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MYOZ2 myozenin 2.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Faulkner G, Pallavicini A, Formentin E, et al. (1999). "ZASP: a new Z-band alternatively spliced PDZ-motif protein.". J. Cell Biol. 146 (2): 465–75. PMID 10427098.
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. doi:10.1073/pnas.260501097. PMID 11114196.
Ahmad F, Gonzalez O, Ramagli L, et al. (2001). "Identification and characterization of a novel gene (C4orf5) located on human chromosome 4q with specific expression in cardiac and skeletal muscle.". Genomics 70 (3): 347–53. doi:10.1006/geno.2000.6399. PMID 11161785.
Takada F, Vander Woude DL, Tong HQ, et al. (2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMID 11171996.
Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gontier Y, Taivainen A, Fontao L, et al. (2006). "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.". J. Cell. Sci. 118 (Pt 16): 3739–49. doi:10.1242/jcs.02484. PMID 16076904.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Osio A, Tan L, Chen SN, et al. (2007). "Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy.". Circ. Res. 100 (6): 766–8. doi:10.1161/01.RES.0000263008.66799.aa. PMID 17347475.
Posch MG, Perrot A, Dietz R, et al. (2007). "Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.". Mol. Genet. Metab. 91 (2): 207–8. doi:10.1016/j.ymgme.2007.02.014. PMID 17434779.