MYOCD

From Wikipedia, the free encyclopedia

Myocardin

Identifiers

External IDs

OMIM: 606127 MGI: 2137495 HomoloGene: 17043

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_153604 (mRNA)
NP_705832 (protein)

NM_145136 (mRNA)
NP_660118 (protein)

Location

Chr 17: 12.51 - 12.61 Mb

Chr 11: 64.99 - 65.09 Mb

Pubmed search

[1]

[2]

Myocardin, also known as MYOCD, is a human gene.^[1]

Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MYOCD myocardin.

[edit] Further reading

Wang D, Chang PS, Wang Z, et al. (2001). "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.". Cell 105 (7): 851–62. PMID 11439182.
Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMID 12397177.
Du KL, Ip HS, Li J, et al. (2003). "Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.". Mol. Cell. Biol. 23 (7): 2425–37. PMID 12640126.
Wang Z, Wang DZ, Pipes GC, Olson EN (2003). "Myocardin is a master regulator of smooth muscle gene expression.". Proc. Natl. Acad. Sci. U.S.A. 100 (12): 7129–34. doi:10.1073/pnas.1232341100. PMID 12756293.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Du KL, Chen M, Li J, et al. (2004). "Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.". J. Biol. Chem. 279 (17): 17578–86. doi:10.1074/jbc.M400961200. PMID 14970199.
Wang Z, Wang DZ, Hockemeyer D, et al. (2004). "Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.". Nature 428 (6979): 185–9. doi:10.1038/nature02382. PMID 15014501.
van Tuyn J, Knaän-Shanzer S, van de Watering MJ, et al. (2006). "Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin.". Cardiovasc. Res. 67 (2): 245–55. doi:10.1016/j.cardiores.2005.04.013. PMID 15907818.
Liu ZP, Wang Z, Yanagisawa H, Olson EN (2005). "Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.". Dev. Cell 9 (2): 261–70. doi:10.1016/j.devcel.2005.05.017. PMID 16054032.
Doi H, Iso T, Yamazaki M, et al. (2006). "HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.". Arterioscler. Thromb. Vasc. Biol. 25 (11): 2328–34. doi:10.1161/01.ATV.0000185829.47163.32. PMID 16151017.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.
Chow N, Bell RD, Deane R, et al. (2007). "Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.". Proc. Natl. Acad. Sci. U.S.A. 104 (3): 823–8. doi:10.1073/pnas.0608251104. PMID 17215356.
Milyavsky M, Shats I, Cholostoy A, et al. (2007). "Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.". Cancer Cell 11 (2): 133–46. doi:10.1016/j.ccr.2006.11.022. PMID 17292825.
Li HJ, Haque Z, Lu Q, et al. (2007). "Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4065–70. doi:10.1073/pnas.0611639104. PMID 17360478.
Pijnappels DA, van Tuyn J, de Vries AA, et al. (2007). "Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts.". Circulation 116 (18): 2018–28. doi:10.1161/CIRCULATIONAHA.107.712935. PMID 17938287.