MYH10

From Wikipedia, the free encyclopedia

Myosin, heavy chain 10, non-muscle

Identifiers

MYH10; MGC134913; MGC134914; NMMHCB

External IDs

OMIM: 160776 MGI: 1930780 HomoloGene: 55941

Gene ontology
Molecular Function:	• nucleotide binding • motor activity • actin binding • calmodulin binding • ATP binding
Cellular Component:	• stress fiber • cytoplasm • cell cortex • myosin complex • midbody • cleavage furrow
Biological Process:	• neuron migration • plasma membrane repair • exocytosis • substrate-bound cell migration, cell extension • adult heart development • biological_process • regulation of cell shape • lateral ventricle development • myofibril assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005964 (mRNA)
NP_005955 (protein)

NM_175260 (mRNA)
NP_780469 (protein)

Location

Chr 17: 8.32 - 8.47 Mb

Chr 11: 68.51 - 68.63 Mb

Pubmed search

[1]

[2]

Myosin, heavy chain 10, non-muscle, also known as MYH10, is a human gene.^[1]

[edit] References

^ Entrez Gene: MYH10 myosin, heavy chain 10, non-muscle.

[edit] Further reading

Simons M, Wang M, McBride OW, et al. (1991). "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.". Circ. Res. 69 (2): 530–9. PMID 1860190.
Phillips CL, Yamakawa K, Adelstein RS (1996). "Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.". J. Muscle Res. Cell. Motil. 16 (4): 379–89. PMID 7499478.
Strand D, Unger S, Corvi R, et al. (1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.". Oncogene 11 (2): 291–301. PMID 7542763.
Maupin P, Phillips CL, Adelstein RS, Pollard TD (1995). "Differential localization of myosin-II isozymes in human cultured cells and blood cells.". J. Cell. Sci. 107 ( Pt 11): 3077–90. PMID 7699007.
Itoh K, Adelstein RS (1995). "Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B.". J. Biol. Chem. 270 (24): 14533–40. PMID 7782316.
Aikawa M, Sivam PN, Kuro-o M, et al. (1993). "Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.". Circ. Res. 73 (6): 1000–12. PMID 7916668.
Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.". Am. J. Pathol. 142 (1): 221–30. PMID 8424456.
Kawamoto S (1996). "Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence.". J. Biol. Chem. 271 (30): 17613–6. PMID 8663598.
Weir L, Chen D (1997). "Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F.". Gene Expr. 6 (1): 45–57. PMID 8931991.
Ford HL, Silver DL, Kachar B, et al. (1998). "Effect of Mts1 on the structure and activity of nonmuscle myosin II.". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Lin VK, Wang D, Lee IL, et al. (2000). "Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue.". Prostate 44 (3): 193–203. PMID 10906735.
Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria.". Mol. Cell. Biol. 20 (18): 6731–40. PMID 10958671.
Wei Q, Adelstein RS (2000). "Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells.". Mol. Biol. Cell 11 (10): 3617–27. PMID 11029059.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang F, Kovacs M, Hu A, et al. (2003). "Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance.". J. Biol. Chem. 278 (30): 27439–48. doi:10.1074/jbc.M302510200. PMID 12704189.
Huang H, Paliouras M, Rambaldi I, et al. (2003). "Nonmuscle myosin promotes cytoplasmic localization of PBX.". Mol. Cell. Biol. 23 (10): 3636–45. PMID 12724421.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Straight AF, Field CM, Mitchison TJ (2005). "Anillin binds nonmuscle myosin II and regulates the contractile ring.". Mol. Biol. Cell 16 (1): 193–201. doi:10.1091/mbc.E04-08-0758. PMID 15496454.
Bastian P, Lang K, Niggemann B, et al. (2005). "Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.". Cell. Mol. Life Sci. 62 (1): 65–76. doi:10.1007/s00018-004-4391-6. PMID 15619008.
Nakasawa T, Takahashi M, Matsuzawa F, et al. (2005). "Critical regions for assembly of vertebrate nonmuscle myosin II.". Biochemistry 44 (1): 174–83. doi:10.1021/bi048807h. PMID 15628858.