MYBPC1

From Wikipedia, the free encyclopedia

Myosin binding protein C, slow type

PDB rendering based on 1x44.

Available structures: 1x44, 2dav

Identifiers

Symbol(s)

MYBPC1; MYBPCC; MYBPCS; slow-type

External IDs

OMIM: 160794 MGI: 1924741 HomoloGene: 1846

Gene ontology
Molecular Function:	• actin binding • protein binding • structural constituent of muscle
Cellular Component:	• cytoplasm • striated muscle thick filament
Biological Process:	• striated muscle contraction • cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002465 (mRNA)
NP_002456 (protein)

NM_175418 (mRNA)
NP_780627 (protein)

Location

Chr 12: 100.51 - 100.6 Mb

Chr 10: 87.95 - 88.02 Mb

Pubmed search

[1]

[2]

Myosin binding protein C, slow type, also known as MYBPC1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MYBPC1 myosin binding protein C, slow type.

[edit] Further reading

Fürst DO, Vinkemeier U, Weber K (1992). "Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA.". J. Cell. Sci. 102 ( Pt 4): 769–78. PMID 1429890.
Johnston LH, Barker DG, Nurse P (1986). "Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17.". Gene 41 (2-3): 321–5. PMID 3011605.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
Weber FE, Vaughan KT, Reinach FC, Fischman DA (1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment.". Eur. J. Biochem. 216 (2): 661–9. PMID 8375400.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA (1997). "Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.". J. Biol. Chem. 272 (33): 20866–72. PMID 9252413.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Welikson RE, Fischman DA (2003). "The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells.". J. Cell. Sci. 115 (Pt 17): 3517–26. PMID 12154082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Konno T, Shimizu M, Ino H, et al. (2003). "A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients.". J. Am. Coll. Cardiol. 41 (5): 781–6. PMID 12628722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beatham J, Romero R, Townsend SK, et al. (2006). "Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres.". Hum. Mol. Genet. 13 (22): 2863–74. doi:10.1093/hmg/ddh308. PMID 15385448.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Dhoot GK, Perry SV (2006). "Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart.". J. Muscle Res. Cell. Motil. 26 (2-3): 143–8. doi:10.1007/s10974-005-3089-1. PMID 16003462.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
McGrath MJ, Cottle DL, Nguyen MA, et al. (2006). "Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.". J. Biol. Chem. 281 (11): 7666–83. doi:10.1074/jbc.M512552200. PMID 16407297.
Flashman E, Watkins H, Redwood C (2007). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.". Biochem. J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMID 16918501.