MUS81

From Wikipedia, the free encyclopedia

MUS81 endonuclease homolog (S. cerevisiae)

Identifiers

MUS81; FLJ21012; FLJ44872

External IDs

OMIM: 606591 MGI: 1918961 HomoloGene: 5725

Gene ontology
Molecular Function:	• magnesium ion binding • nucleic acid binding • nuclease activity • endonuclease activity • hydrolase activity • sequence-specific DNA binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA metabolic process • DNA repair • DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025128 (mRNA)
NP_079404 (protein)

NM_027877 (mRNA)
NP_082153 (protein)

Location

Chr 11: 65.38 - 65.39 Mb

Chr 19: 5.48 - 5.49 Mb

Pubmed search

[1]

[2]

MUS81 endonuclease homolog (S. cerevisiae), also known as MUS81, is a human gene.^[1]

[edit] References

^ Entrez Gene: MUS81 MUS81 endonuclease homolog (S. cerevisiae).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Boddy MN, Lopez-Girona A, Shanahan P, et al. (2000). "Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.". Mol. Cell. Biol. 20 (23): 8758-66. PMID 11073977.
Chen XB, Melchionna R, Denis CM, et al. (2002). "Human Mus81-associated endonuclease cleaves Holliday junctions in vitro.". Mol. Cell 8 (5): 1117-27. PMID 11741546.
Constantinou A, Chen XB, McGowan CH, West SC (2002). "Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities.". EMBO J. 21 (20): 5577-85. PMID 12374758.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Oğrünç M, Sancar A (2003). "Identification and characterization of human MUS81-MMS4 structure-specific endonuclease.". J. Biol. Chem. 278 (24): 21715-20. doi:10.1074/jbc.M302484200. PMID 12686547.
Ciccia A, Constantinou A, West SC (2003). "Identification and characterization of the human mus81-eme1 endonuclease.". J. Biol. Chem. 278 (27): 25172-8. doi:10.1074/jbc.M302882200. PMID 12721304.
Blais V, Gao H, Elwell CA, et al. (2004). "RNA interference inhibition of Mus81 reduces mitotic recombination in human cells.". Mol. Biol. Cell 15 (2): 552-62. doi:10.1091/mbc.E03-08-0580. PMID 14617801.
Gao H, Chen XB, McGowan CH (2004). "Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells.". Mol. Biol. Cell 14 (12): 4826-34. doi:10.1091/mbc.E03-05-0276. PMID 14638871.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang R, Sengupta S, Yang Q, et al. (2005). "BLM helicase facilitates Mus81 endonuclease activity in human cells.". Cancer Res. 65 (7): 2526-31. doi:10.1158/0008-5472.CAN-04-2421. PMID 15805243.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Hiyama T, Katsura M, Yoshihara T, et al. (2006). "Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.". Nucleic Acids Res. 34 (3): 880-92. doi:10.1093/nar/gkj495. PMID 16456034.
Ii M, Ii T, Brill SJ (2007). "Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae.". Mutat. Res. 625 (1-2): 1-19. doi:10.1016/j.mrfmmm.2007.04.007. PMID 17555773.
Nomura Y, Adachi N, Koyama H (2007). "Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.". Genes Cells 12 (10): 1111-22. doi:10.1111/j.1365-2443.2007.01124.x. PMID 17903171.