Multiple inositol-polyphosphate phosphatase

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In enzymology, a multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) is an enzyme that catalyzes the chemical reaction

myo-inositol hexakisphosphate + H₂O $\rightleftharpoons$ myo-inositol pentakisphosphate (mixed isomers) + phosphate

Thus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H₂O, whereas its two products are myo-inositol pentakisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase. Other names in common use include inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase, inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase, inositol tetrakisphosphate phosphomonoesterase, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase, and MIPP. This enzyme participates in inositol phosphate metabolism.

[edit] References

IUBMB entry for 3.1.3.62
BRENDA references for 3.1.3.62 (Recommended.)
PubMed references for 3.1.3.62
PubMed Central references for 3.1.3.62
Google Scholar references for 3.1.3.62
Cullen PJ, Irvine RF, Drobak BK, Dawson AP (1989). "Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate". Biochem. J. 259: 931–3. PMID 2786415.
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB (Pt 1). "Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase". Biochem. J. 328: 75–81. PMID 9359836.