MUC17

From Wikipedia, the free encyclopedia

Mucin 17, cell surface associated

Identifiers

External IDs

OMIM: 608424 MGI: 1203527 HomoloGene: 88635

Gene ontology
Molecular Function:	• extracellular matrix constituent, lubricant activity
Cellular Component:	• cellular_component
Biological Process:	• biological_process

Orthologs

Human

Mouse

n/a

Refseq

NM_001040105 (mRNA)
NP_001035194 (protein)

XM_355711 (mRNA)
XP_355711 (protein)

Location

Chr 7: 100.45 - 100.49 Mb

n/a

Pubmed search

[1]

[2]

Mucin 17, cell surface associated, also known as MUC17, is a human gene.^[1]

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MUC17 mucin 17, cell surface associated.

[edit] Further reading

Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine.". Biochem. J. 410 (2): 283-9. doi:10.1042/BJ20071068. PMID 17990980.
Moniaux N, Junker WM, Singh AP, et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization.". J. Biol. Chem. 281 (33): 23676-85. doi:10.1074/jbc.M600302200. PMID 16737958.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Ho JJ, Jaituni RS, Crawley SC, et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin.". Int. J. Oncol. 23 (3): 585-92. PMID 12888891.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components.". Biochem. J. 366 (Pt 2): 623-31. doi:10.1042/BJ20020289. PMID 12027806.
Gum JR, Crawley SC, Hicks JW, et al. (2002). "MUC17, a novel membrane-tethered mucin.". Biochem. Biophys. Res. Commun. 291 (3): 466-75. doi:10.1006/bbrc.2002.6475. PMID 11855812.
Van Klinken BJ, Van Dijken TC, Oussoren E, et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region.". Biochem. Biophys. Res. Commun. 238 (1): 143-8. doi:10.1006/bbrc.1997.7258. PMID 9299468.