MTX1

From Wikipedia, the free encyclopedia


Metaxin 1
Identifiers
Symbol(s) MTX1; MTX; MTXN
External IDs OMIM: 600605 MGI: 103025 HomoloGene: 37623
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4580 17827
Ensembl ENSG00000173171 ENSMUSG00000064068
Uniprot Q13505 Q8R5C0
Refseq NM_002455 (mRNA)
NP_002446 (protein)		 NM_013604 (mRNA)
NP_038632 (protein)
Location Chr 1: 153.45 - 153.45 Mb Chr 3: 89.3 - 89.3 Mb
Pubmed search [1] [2]

Metaxin 1, also known as MTX1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MTX1 metaxin 1.

[edit] Further reading

  • Bornstein P, McKinney CE, LaMarca ME, et al. (1995). "Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease.". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4547–51. PMID 7753840. 
  • Long GL, Winfield S, Adolph KW, et al. (1997). "Structure and organization of the human metaxin gene (MTX) and pseudogene.". Genomics 33 (2): 177–84. doi:10.1006/geno.1996.0181. PMID 8660965. 
  • Armstrong LC, Komiya T, Bergman BE, et al. (1997). "Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion.". J. Biol. Chem. 272 (10): 6510–8. PMID 9045676. 
  • Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.". Genome Res. 7 (10): 1020–6. PMID 9331372. 
  • Armstrong LC, Saenz AJ, Bornstein P (1999). "Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane.". J. Cell. Biochem. 74 (1): 11–22. PMID 10381257. 
  • Abdul KM, Terada K, Yano M, et al. (2000). "Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex.". Biochem. Biophys. Res. Commun. 276 (3): 1028–34. doi:10.1006/bbrc.2000.3589. PMID 11027586. 
  • Wang X, Ono K, Kim SO, et al. (2001). "Metaxin is required for tumor necrosis factor-induced cell death.". EMBO Rep. 2 (7): 628–33. doi:10.1093/embo-reports/kve135. PMID 11454742. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • LaMarca ME, Goldstein M, Tayebi N, et al. (2004). "A novel alteration in metaxin 1, F202L, is associated with N370S in Gaucher disease.". J. Hum. Genet. 49 (4): 220–2. doi:10.1007/s10038-004-0134-7. PMID 15024629. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Kozjak-Pavlovic V, Ross K, Benlasfer N, et al. (2007). "Conserved roles of Sam50 and metaxins in VDAC biogenesis.". EMBO Rep. 8 (6): 576–82. doi:10.1038/sj.embor.7400982. PMID 17510655. 
  • Xie J, Marusich MF, Souda P, et al. (2007). "The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.". FEBS Lett. 581 (18): 3545–9. doi:10.1016/j.febslet.2007.06.052. PMID 17624330. 
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