MTMR6

From Wikipedia, the free encyclopedia

Myotubularin related protein 6

Identifiers

External IDs

OMIM: 603561 MGI: 2145637 HomoloGene: 55842

Gene ontology
Molecular Function:	• inositol or phosphatidylinositol phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • hydrolase activity
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• protein amino acid dephosphorylation • phospholipid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004685 (mRNA)
NP_004676 (protein)

NM_144843 (mRNA)
NP_659092 (protein)

Location

Chr 13: 24.72 - 24.76 Mb

Chr 14: 59.22 - 59.26 Mb

Pubmed search

[1]

[2]

Myotubularin related protein 6, also known as MTMR6, is a human gene.^[1]

[edit] References

^ Entrez Gene: MTMR6 myotubularin related protein 6.

[edit] Further reading

Laporte J, Blondeau F, Buj-Bello A, et al. (1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.". Hum. Mol. Genet. 7 (11): 1703-12. PMID 9736772.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Schaletzky J, Dove SK, Short B, et al. (2004). "Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.". Curr. Biol. 13 (6): 504-9. PMID 12646134.
Nandurkar HH, Layton M, Laporte J, et al. (2003). "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8660-5. doi:10.1073/pnas.1033097100. PMID 12847286.
Mochizuki Y, Majerus PW (2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768-73. doi:10.1073/pnas.1333958100. PMID 12890864.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Srivastava S, Ko K, Choudhury P, et al. (2006). "Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells.". Mol. Cell. Biol. 26 (15): 5595-602. doi:10.1128/MCB.00352-06. PMID 16847315.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.