MTIF2

From Wikipedia, the free encyclopedia

Mitochondrial translational initiation factor 2

Identifiers

External IDs

OMIM: 603766 MGI: 1924034 HomoloGene: 1840

Gene ontology
Molecular Function:	• nucleotide binding • translation initiation factor activity • GTPase activity • GTP binding • ribosomal small subunit binding
Cellular Component:	• intracellular • mitochondrion
Biological Process:	• regulation of translational initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001005369 (mRNA)
NP_001005369 (protein)

NM_133767 (mRNA)
NP_598528 (protein)

Location

Chr 2: 55.32 - 55.34 Mb

Chr 11: 29.43 - 29.45 Mb

Pubmed search

[1]

[2]

Mitochondrial translational initiation factor 2, also known as MTIF2, is a human gene.^[1]

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: MTIF2 mitochondrial translational initiation factor 2.

[edit] Further reading

Ma L, Spremulli LL (1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA.". J. Biol. Chem. 270 (4): 1859-65. PMID 7829522.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Bonner DS, Wiley JE, Farwell MA (1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16-->p14 by in situ hybridization and with somatic cell hybrids.". Cytogenet. Cell Genet. 83 (1-2): 80-1. PMID 9925935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene.". Biochim. Biophys. Acta 1628 (3): 195-205. PMID 12932832.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Miura E, Kato Y, Matsushima R, et al. (2007). "The balance between protein synthesis and degradation in chloroplasts determines leaf variegation in Arabidopsis yellow variegated mutants.". Plant Cell 19 (4): 1313-28. doi:10.1105/tpc.106.049270. PMID 17416734.