MSI1

From Wikipedia, the free encyclopedia

Musashi homolog 1 (Drosophila)

PDB rendering based on 1uaw.

Available structures: 1uaw, 2mss, 2mst

Identifiers

Symbol(s)

MSI1;

External IDs

OMIM: 603328 MGI: 107376 HomoloGene: 55657

Gene ontology
Molecular Function:	• nucleotide binding • poly(U) binding
Cellular Component:	• nucleus • cytoplasm • polysome
Biological Process:	• nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002442 (mRNA)
NP_002433 (protein)

XM_988026 (mRNA)
XP_993120 (protein)

Location

Chr 12: 119.26 - 119.29 Mb

Chr 5: 115.69 - 115.72 Mb

Pubmed search

[1]

[2]

Musashi homolog 1 (Drosophila), also known as MSI1, is a human gene.^[1]

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.^[1]

[edit] References

^ ^a ^b Entrez Gene: MSI1 musashi homolog 1 (Drosophila).

[edit] Further reading

Okano H, Imai T, Okabe M (2002). "Musashi: a translational regulator of cell fate.". J. Cell. Sci. 115 (Pt 7): 1355-9. PMID 11896183.
Good P, Yoda A, Sakakibara S, et al. (1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells.". Genomics 52 (3): 382-4. PMID 9790759.
Toda M, Iizuka Y, Yu W, et al. (2001). "Expression of the neural RNA-binding protein Musashi1 in human gliomas.". Glia 34 (1): 1-7. PMID 11284014.
Imai T, Tokunaga A, Yoshida T, et al. (2001). "The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.". Mol. Cell. Biol. 21 (12): 3888-900. doi:10.1128/MCB.21.12.3888-3900.2001. PMID 11359897.
Sakakibara S, Nakamura Y, Satoh H, Okano H (2001). "Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS.". J. Neurosci. 21 (20): 8091-107. PMID 11588182.
Kanemura Y, Mori K, Sakakibara S, et al. (2002). "Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity.". Differentiation 68 (2-3): 141-52. PMID 11686236.
Kanemura Y, Sakakibara S, Okano H (2002). "Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods.". Methods Mol. Biol. 198: 273-81. doi:10.1385/1-59259-186-8:273. PMID 11951628.
Shu HJ, Saito T, Watanabe H, et al. (2002). "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines.". Biochem. Biophys. Res. Commun. 293 (1): 150-4. doi:10.1016/S0006-291X(02)00175-4. PMID 12054577.
Miyanoiri Y, Kobayashi H, Imai T, et al. (2003). "Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics.". J. Biol. Chem. 278 (42): 41309-15. doi:10.1074/jbc.M306210200. PMID 12907678.
Nishimura S, Wakabayashi N, Toyoda K, et al. (2003). "Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium.". Dig. Dis. Sci. 48 (8): 1523-9. PMID 12924647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lovell MA, Markesbery WR (2005). "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease.". J. Neuropathol. Exp. Neurol. 64 (8): 675-80. PMID 16106215.
Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM (2006). "The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1.". Mol. Cell. Neurosci. 31 (1): 85-96. doi:10.1016/j.mcn.2005.09.003. PMID 16214366.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346-51. doi:10.1038/nature04569. PMID 16541075.
Chan C, Moore BE, Cotman CW, et al. (2006). "Musashi1 antigen expression in human fetal germinal matrix development.". Exp. Neurol. 201 (2): 515-8. doi:10.1016/j.expneurol.2006.04.023. PMID 16777095.