MSC (gene)

From Wikipedia, the free encyclopedia

Musculin (activated B-cell factor-1)

Identifiers

MSC; ABF-1; ABF1; MYOR

External IDs

OMIM: 603628 MGI: 1333884 HomoloGene: 3738

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005098 (mRNA)
NP_005089 (protein)

NM_010827 (mRNA)
NP_034957 (protein)

Location

Chr 8: 72.92 - 72.92 Mb

Chr 1: 14.74 - 14.74 Mb

Pubmed search

[1]

[2]

Musculin (activated B-cell factor-1), also known as MSC, is a human gene.^[1]

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: MSC musculin (activated B-cell factor-1).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Massari ME, Rivera RR, Voland JR, et al. (1998). "Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.". Mol. Cell. Biol. 18 (6): 3130-9. PMID 9584154.
Robb L, Hartley L, Wang CC, et al. (1998). "musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle.". Mech. Dev. 76 (1-2): 197-201. PMID 9767165.
Robb L, Brodnicki T, Copeland NG, et al. (1999). "Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1.". Genomics 57 (2): 318-9. doi:10.1006/geno.1999.5764. PMID 10198176.
Wong J, Funes-Duran M, Ahlberg J, et al. (2001). "Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2.". DNA Cell Biol. 20 (8): 465-71. doi:10.1089/104454901316976091. PMID 11560778.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Knight JC, Keating BJ, Kwiatkowski DP (2004). "Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.". Nat. Genet. 36 (4): 394-9. doi:10.1038/ng1331. PMID 15052269.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.