MRVI1
From Wikipedia, the free encyclopedia
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Murine retrovirus integration site 1 homolog
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| Identifiers | ||||||||
| Symbol(s) | MRVI1; IRAG; JAW1L | |||||||
| External IDs | OMIM: 604673 MGI: 1338023 HomoloGene: 4425 | |||||||
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| RNA expression pattern | ||||||||
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| Orthologs | ||||||||
| Human | Mouse | |||||||
| Entrez | 10335 | 17540 | ||||||
| Ensembl | ENSG00000072952 | ENSMUSG00000005611 | ||||||
| Refseq | NM_006069 (mRNA) NP_006060 (protein) |
NM_010826 (mRNA) NP_034956 (protein) |
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| Location | Chr 11: 10.55 - 10.63 Mb | Chr 7: 110.66 - 110.77 Mb | ||||||
| Pubmed search | [1] | [2] | ||||||
Murine retrovirus integration site 1 homolog, also known as MRVI1, is a human gene.[1]
This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[1]
[edit] References
[edit] Further reading
- Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. doi:. PMID 1538749.
- Baltensperger K, Chiesi M, Carafoli E (1991). "Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process.". Biochemistry 29 (41): 9753–60. PMID 2271613.
- Shaughnessy JD, Largaespada DA, Tian E, et al. (1999). "Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.". Oncogene 18 (12): 2069–84. doi:. PMID 10321731.
- Schlossmann J, Ammendola A, Ashman K, et al. (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.". Nature 404 (6774): 197–201. doi:. PMID 10724174.
- Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta.". J. Biol. Chem. 276 (26): 24153–9. doi:. PMID 11309393.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Koller A, Schlossmann J, Ashman K, et al. (2003). "Association of phospholamban with a cGMP kinase signaling complex.". Biochem. Biophys. Res. Commun. 300 (1): 155–60. PMID 12480535.
- Fritsch RM, Saur D, Kurjak M, et al. (2004). "InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.". J. Biol. Chem. 279 (13): 12551–9. doi:. PMID 14729908.
- Casteel DE, Boss GR, Pilz RB (2006). "Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif.". J. Biol. Chem. 280 (46): 38211–8. doi:. PMID 16166082.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:. PMID 16344560.
- Antl M, von Brühl ML, Eiglsperger C, et al. (2007). "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.". Blood 109 (2): 552–9. doi:. PMID 16990611.
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