MRPL23

From Wikipedia, the free encyclopedia

Mitochondrial ribosomal protein L23

Identifiers

MRPL23; L23MRP; RPL23; RPL23L

External IDs

OMIM: 600789 MGI: 1196612 HomoloGene: 7922

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • structural constituent of ribosome
Cellular Component:	• mitochondrion • mitochondrial large ribosomal subunit • ribonucleoprotein complex
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021134 (mRNA)
NP_066957 (protein)

NM_011288 (mRNA)
NP_035418 (protein)

Location

Chr 11: 1.92 - 1.96 Mb

Chr 7: 142.34 - 142.35 Mb

Pubmed search

[1]

[2]

Mitochondrial ribosomal protein L23, also known as MRPL23, is a human gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.^[1]

[edit] References

^ ^a ^b Entrez Gene: MRPL23 mitochondrial ribosomal protein L23.

[edit] Further reading

Sun XX, Dai MS, Lu H (2007). "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction.". J. Biol. Chem. 282 (11): 8052-9. doi:10.1074/jbc.M610621200. PMID 17242401.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease.". Gene 286 (1): 73-9. PMID 11943462.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65-70. doi:10.1006/geno.2001.6622. PMID 11543634.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.". J. Biol. Chem. 276 (24): 21724-36. doi:10.1074/jbc.M100432200. PMID 11279069.
Tsang P, Gilles F, Yuan L, et al. (1996). "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.". Hum. Mol. Genet. 4 (9): 1499-507. PMID 8541832.