MRAS

From Wikipedia, the free encyclopedia

Muscle RAS oncogene homolog

PDB rendering based on 1x1r.

Available structures: 1x1r, 1x1s

Identifiers

Symbol(s)

MRAS; FLJ42964; M-RAs; R-RAS3; RRAS3

External IDs

OMIM: 608435 MGI: 1100856 HomoloGene: 7424

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding • GTP-dependent protein binding
Cellular Component:	• intracellular • plasma membrane
Biological Process:	• Ras protein signal transduction • multicellular organismal development • muscle development • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012219 (mRNA)
NP_036351 (protein)

NM_008624 (mRNA)
NP_032650 (protein)

Location

Chr 3: 139.55 - 139.6 Mb

Chr 9: 99.2 - 99.24 Mb

Pubmed search

[1]

[2]

Muscle RAS oncogene homolog, also known as MRAS, is a human gene.^[1]

Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MRAS muscle RAS oncogene homolog.

[edit] Further reading

Matsumoto K, Asano T, Endo T (1997). "Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton.". Oncogene 15 (20): 2409–17. doi:10.1038/sj.onc.1201416. PMID 9395237.
Kimmelman A, Tolkacheva T, Lorenzi MV, et al. (1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution.". Oncogene 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
Quilliam LA, Castro AF, Rogers-Graham KS, et al. (1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.". J. Biol. Chem. 274 (34): 23850–7. PMID 10446149.
Louahed J, Grasso L, De Smet C, et al. (1999). "Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones.". Blood 94 (5): 1701–10. PMID 10477695.
Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line.". Blood 94 (7): 2433–44. PMID 10498616.
Kimmelman AC, Osada M, Chan AM (2000). "R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells.". Oncogene 19 (16): 2014–22. doi:10.1038/sj.onc.1203530. PMID 10803462.
Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
Gao X, Satoh T, Liao Y, et al. (2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras.". J. Biol. Chem. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Kimmelman AC, Nuñez Rodriguez N, Chan AM (2002). "R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.". Mol. Cell. Biol. 22 (16): 5946–61. PMID 12138204.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Roberts AE, Araki T, Swanson KD, et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome.". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
Yoshikawa Y, Satoh T, Tamura T, et al. (2007). "The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.". Mol. Biol. Cell 18 (8): 2949–59. doi:10.1091/mbc.E07-03-0250. PMID 17538012.