MR1

From Wikipedia, the free encyclopedia

Major histocompatibility complex, class I-related

Identifiers

MR1; HLALS

External IDs

OMIM: 600764 MGI: 1195463 HomoloGene: 74400

Gene ontology
Molecular Function:	• MHC class I receptor activity
Cellular Component:	• membrane • integral to membrane • MHC class I protein complex
Biological Process:	• antigen processing and presentation of peptide antigen via MHC class I • immune response • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001531 (mRNA)
NP_001522 (protein)

NM_008209 (mRNA)
NP_032235 (protein)

Location

Chr 1: 179.27 - 179.29 Mb

Chr 1: 156.89 - 156.91 Mb

Pubmed search

[1]

[2]

Major histocompatibility complex, class I-related, also known as MR1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MR1 major histocompatibility complex, class I-related.

[edit] Further reading

Hashimoto K, Hirai M, Kurosawa Y (1995). "A gene outside the human MHC related to classical HLA class I genes.". Science 269 (5224): 693-5. PMID 7624800.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (1997). "A highly conserved major histocompatibility complex class I-related gene in mammals.". Biochem. Biophys. Res. Commun. 238 (3): 697-702. doi:10.1006/bbrc.1997.7379. PMID 9325151.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Riegert P, Wanner V, Bahram S (1998). "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.". J. Immunol. 161 (8): 4066-77. PMID 9780177.
Yamaguchi H, Kurosawa Y, Hashimoto K (1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog.". Biochem. Biophys. Res. Commun. 250 (3): 558-64. doi:10.1006/bbrc.1998.9353. PMID 9784382.
Parra-Cuadrado JF, Navarro P, Mirones I, et al. (2001). "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene.". Tissue Antigens 56 (2): 170-2. PMID 11019920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Miley MJ, Truscott SM, Yu YY, et al. (2003). "Biochemical features of the MHC-related protein 1 consistent with an immunological function.". J. Immunol. 170 (12): 6090-8. PMID 12794138.
Hempelmann A, Kumar S, Muralitharan S, Sander T (2007). "Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia.". Neurosci. Lett. 402 (1-2): 118-20. doi:10.1016/j.neulet.2006.03.048. PMID 16632198.