MPZL1

From Wikipedia, the free encyclopedia

Myelin protein zero-like 1

Identifiers

MPZL1; FLJ21047; PZR; PZR1b; PZRa; PZRb

External IDs

OMIM: 604376 MGI: 1915731 HomoloGene: 2939

Gene ontology
Molecular Function:	• structural molecule activity • protein binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• transmembrane receptor protein tyrosine kinase signaling pathway • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003953 (mRNA)
NP_003944 (protein)

NM_001001880 (mRNA)
NP_001001880 (protein)

Location

Chr 1: 165.96 - 166.03 Mb

Chr 1: 167.44 - 167.47 Mb

Pubmed search

[1]

[2]

Myelin protein zero-like 1, also known as MPZL1, is a human gene.^[1]

[edit] References

^ Entrez Gene: MPZL1 myelin protein zero-like 1.

[edit] Further reading

Zhao ZJ, Zhao R (1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.". J. Biol. Chem. 273 (45): 29367-72. PMID 9792637.
Zhao R, Zhao ZJ (2000). "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.". J. Biol. Chem. 275 (8): 5453-9. PMID 10681522.
Zhao R, Guerrah A, Tang H, Zhao ZJ (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.". J. Biol. Chem. 277 (10): 7882-8. doi:10.1074/jbc.M111914200. PMID 11751924.
Tang DS, Yu KP, Tang XX, et al.. "Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics Strategy." 32 (4): 364-368. PMID 12075424.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410.
Zannettino AC, Roubelakis M, Welldon KJ, et al. (2003). "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.". Biochem. J. 370 (Pt 2): 537-49. doi:10.1042/BJ20020935. PMID 12410637.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhao R, Zhao ZJ (2003). "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.". Biochem. Biophys. Res. Commun. 303 (4): 1028-33. PMID 12684038.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets.". Methods 35 (1): 44-53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
He G, Liu X, Qin W, et al. (2006). "MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese.". Mol. Psychiatry 11 (8): 748-51. doi:10.1038/sj.mp.4001841. PMID 16702974.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.