MPP5

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Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
PDB rendering based on 1va8.
Available structures: 1va8, 1y76
Identifiers
Symbol(s) MPP5; FLJ12615; PALS1
External IDs OMIM: 606958 MGI: 1927339 HomoloGene: 9512
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 64398 56217
Ensembl ENSG00000072415 ENSMUSG00000021112
Uniprot Q8N3R9 Q9JLB2
Refseq NM_022474 (mRNA)
NP_071919 (protein)		 NM_019579 (mRNA)
NP_062525 (protein)
Location Chr 14: 66.78 - 66.87 Mb Chr 12: 79.67 - 79.76 Mb
Pubmed search [1] [2]

Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5), also known as MPP5, is a human gene.[1]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5).

[edit] Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7.". J. Biol. Chem. 275 (15): 11425–31. PMID 10753959. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.". Biochim. Biophys. Acta 1518 (3): 249–59. PMID 11311936. 
  • Roh MH, Makarova O, Liu CJ, et al. (2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMID 11927608. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).". Gene 302 (1-2): 21–9. PMID 12527193. 
  • Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. 
  • Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.". J. Cell. Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Penkert RR, DiVittorio HM, Prehoda KE (2004). "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.". Nat. Struct. Mol. Biol. 11 (11): 1122–7. doi:10.1038/nsmb839. PMID 15475968. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Stöhr H, Molday LL, Molday RS, et al. (2005). "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.". J. Comp. Neurol. 481 (1): 31–41. doi:10.1002/cne.20367. PMID 15558731. 
  • Feng W, Long JF, Zhang M (2005). "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. doi:10.1073/pnas.0409346102. PMID 15863617. 
  • Kantardzhieva A, Gosens I, Alexeeva S, et al. (2005). "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors.". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. doi:10.1167/iovs.04-1417. PMID 15914641. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
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