Monosialoganglioside sialyltransferase

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In enzymology, a monosialoganglioside sialyltransferase (EC 2.4.99.2) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide $\rightleftharpoons$ CMP + N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide

The 3 substrates of this enzyme are CMP-N-acetylneuraminate, D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-, and galactosyl-D-glucosylceramide, whereas its 3 products are CMP, N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-, and acetylneuraminyl)-D-galactosyl-D-glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-ac etylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase.

[edit] References

IUBMB entry for 2.4.99.2
BRENDA references for 2.4.99.2 (Recommended.)
PubMed references for 2.4.99.2
PubMed Central references for 2.4.99.2
Google Scholar references for 2.4.99.2
Rearick JI, Sadler JE, Paulson JC, Hill RL (1979). "Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland". J. Biol. Chem. 254: 4444–51. PMID 438198.
Yip MC (1973). "The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: monosialoganglioside (G M1 ) sialyltransferase". Biochim. Biophys. Acta. 306: 298–306. PMID 4351506.