MLANA

From Wikipedia, the free encyclopedia


Melan-A
Identifiers
Symbol(s) MLANA; MART-1; MART1
External IDs OMIM: 605513 MGI: 108454 HomoloGene: 4026
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2315 77836
Ensembl ENSG00000120215 ENSMUSG00000024806
Uniprot Q16655 n/a
Refseq NM_005511 (mRNA)
NP_005502 (protein)		 XM_129166 (mRNA)
XP_129166 (protein)
Location Chr 9: 5.88 - 5.9 Mb Chr 19: 29.76 - 29.77 Mb
Pubmed search [1] [2]

Melan-A, also known as MLANA, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MLANA melan-A.

[edit] Further reading

  • Coulie PG, Brichard V, Van Pel A, et al. (1994). "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.". J. Exp. Med. 180 (1): 35–42. PMID 8006593. 
  • Kawakami Y, Eliyahu S, Delgado CH, et al. (1994). "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.". Proc. Natl. Acad. Sci. U.S.A. 91 (9): 3515–9. PMID 8170938. 
  • Zippelius A, Pittet MJ, Batard P, et al. (2002). "Thymic selection generates a large T cell pool recognizing a self-peptide in humans.". J. Exp. Med. 195 (4): 485–94. PMID 11854361. 
  • Moritake H, Sugimoto T, Asada Y, et al. (2002). "Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene.". Cancer Genet. Cytogenet. 135 (1): 48–56. PMID 12072203. 
  • Dutoit V, Rubio-Godoy V, Pittet MJ, et al. (2002). "Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans.". J. Exp. Med. 196 (2): 207–16. PMID 12119345. 
  • Mantovani S, Palermo B, Garbelli S, et al. (2002). "Dominant TCR-alpha requirements for a self antigen recognition in humans.". J. Immunol. 169 (11): 6253–60. PMID 12444131. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Du J, Miller AJ, Widlund HR, et al. (2003). "MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma.". Am. J. Pathol. 163 (1): 333–43. PMID 12819038. 
  • Mandelcorn-Monson RL, Shear NH, Yau E, et al. (2003). "Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients.". J. Invest. Dermatol. 121 (3): 550–6. doi:10.1046/j.1523-1747.2003.12413.x. PMID 12925214. 
  • Ghorab Z, Jorda M, Ganjei P, Nadji M (2004). "Melan A (A103) is expressed in adrenocortical neoplasms but not in renal cell and hepatocellular carcinomas.". Appl. Immunohistochem. Mol. Morphol. 11 (4): 330–3. PMID 14663359. 
  • Murer K, Urosevic M, Willers J, et al. (2005). "Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients.". Melanoma Res. 14 (4): 257–62. PMID 15305155. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kucher C, Zhang PJ, Pasha T, et al. (2005). "Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi.". The American Journal of dermatopathology 26 (6): 452–7. PMID 15618925. 
  • Hoashi T, Watabe H, Muller J, et al. (2005). "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.". J. Biol. Chem. 280 (14): 14006–16. doi:10.1074/jbc.M413692200. PMID 15695812. 
  • Godefroy E, Scotto L, Souleimanian NE, et al. (2006). "Identification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles.". Clin. Immunol. 121 (1): 54–62. doi:10.1016/j.clim.2006.05.007. PMID 16814609. 
  • Kono M, Dunn IS, Durda PJ, et al. (2007). "Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.". Mol. Cancer Res. 4 (10): 779–92. doi:10.1158/1541-7786.MCR-06-0077. PMID 17050671. 
  • Bioley G, Jandus C, Tuyaerts S, et al. (2007). "Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.". J. Immunol. 177 (10): 6769–79. PMID 17082590. 
  • Roma AA, Magi-Galluzzi C, Zhou M (2007). "Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas.". Arch. Pathol. Lab. Med. 131 (1): 122–5. PMID 17227112. 
  • Yuan F, Georgiou T, Hillon T, et al. (2007). "Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 758–60. doi:10.1107/S1744309107037244. PMID 17768347. 
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