Mitogen-activated protein kinase kinase

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MAP kinase activation Mitogen ↓ MAP kinase kinase kinase (MAP3K or MKKK) ↓ MAP kinase kinase (MAP2K or MKK) ↓ MAP kinase ↓ further signalling

Mitogen-activated protein kinase kinase (sic) is a kinase enzyme which phosphorylates mitogen-activated protein kinase. It is also known as MAP2K. It is classified as EC 2.7.12.2.

There are seven genes:

• MAP2K1 (aka MEK1)
• MAP2K2 (aka MEK2)
• MAP2K3 (aka MKK3)
• MAP2K4 (aka MKK4}
• MAP2K5 (aka MKK5)
• MAP2K6 (aka MKK6)
• MAP2K7 (aka MKK7)

The activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.^[1]

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• MeSH Mitogen-Activated+Protein+Kinase+Kinases

v • d • e Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11) 2.7.11 Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G Protein kinase C (Protein kinase Mζ) G-protein coupled receptor kinases (Rhodopsin, Beta adrenergic receptor) Ca2+/calmodulin-dependent (Elongation factor 2 kinase, Myosin light-chain) Phosphorylase - Cyclin-dependent Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) MAP3K - GSK-3 - AMP-activated 2.7.12 MAP2K (1, 2, 3, 4, 5, 6, 7) 2.7.1.37, or unknown Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1