Missouri Route 81
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| Route 81 |
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| Maintained by MoDOT | |||||||||||||
| Length: | 43 mi (69 km) | ||||||||||||
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| North end: | Iowa state line | ||||||||||||
| Major junctions: |
 Route 16 West of Canton US 136 South of Kahoka |
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| South end: | West of Canton | ||||||||||||
| Major cities: | Kahoka St. Patrick Canton |
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Route 81 is a highway in northeastern Missouri. Its northern terminus is at the Iowa state line where it continues as Iowa Highway 81. Its souther terminus is at Route 16 west of Canton.
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