Missouri Route 22
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| Route 22 |
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| Maintained by MoDOT | |||||||||||||
| Length: | 23 mi (37 km) | ||||||||||||
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| Formed: | 1922 | ||||||||||||
| East end: |  Route 15 in Mexico |
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| West end: |  US 63 south of Clark |
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| Major cities: | Mexico Centralia |
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Route 22 is a highway in central Missouri. Its eastern terminus is at Route 15 in Mexico; its western terminus is at U.S. Route 63 south of Clark on the Randolph/Boone county line. Route 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54.
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