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| mir-199 microRNA precursor |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
99.9 nucleotides |
| Avg identity: |
88% |
|
The miR-199 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human [1] [2] [3] (MIPF0000040). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The mature products are thought to have regulatory roles through complementarity to mRNA [4].
[edit] References
- ^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA 9 (2): 175–9. PMID 12554859.
- ^ Houbaviy HB, Murray MF, Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev. Cell 5 (2): 351–8. PMID 12919684.
- ^ Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G (2003). "Numerous microRNPs in neuronal cells containing novel microRNAs". RNA 9 (2): 180–6. PMID 12554860.
- ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. PMID 11779458.
[edit] External links
