Mir-10 microRNA precursor family

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mir-10 microRNA precursor family
Template:Abbreviation
Type: Gene; miRNA;
2° structure: Predicted; PFOLD
Seed alignment: Griffiths-Jones SR
Avg length: 73.8 nucleotides
Avg identity: 67%

The miR-10 microRNA precursor, is a short non-coding RNA gene involved in gene regulation. It is also part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species[1][2] (MIPF0000033, MIPF0000025). mir-51 and mir-57 have currently only been identified in the nematode Caenorhabditis elegans (MIPF0000268, MIPF0000271). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.

[edit] References

  1. ^ Lee, RC; Ambros V (2001). "An extensive class of small RNAs in Caenorhabditis elegans". Science 294: 862–864. doi:10.1126/science.1065329. PMID 11679672. 
  2. ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107: 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 

[edit] External links