Talk:Minisatellite
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Isn't this synonymous with "VNTR" (variable number tandem repeat) ?.. Or are they different?
--Hughitt1 04:25, 18 December 2005 (UTC)
[edit] microsatellites and minisatellites
Aren't they the same thing? I'd really appreciate if someone defines on each page the difference between those two and VNTR if there are any
[edit] Microsatellites and minisatellites
Microsatellites are shorter repeats, most typically 1-2 basepairs long. Microsatellites are caused by repeat slippage which is limited to offsets of only a couple of bases.
[edit] micro and mini
Ellegren, 2004 has a nice little explanation:
What is a microsatellite? Genomes are scattered with simple repeats. Tandem repeats occur in the form of iterations of repeat units of almost anything from a single base pair to thousands of base pairs.Mono-, di-, triand tetranucleotide repeats are the main types of microsatellite, but repeats of five (penta-) or six (hexa-) nucleotides are usually classified as microsatellites as well. Repeats of longer units form minisatellites or, in the extreme case, satellite DNA. The term satellite DNA originates from the observation in the 1960s of a fraction of sheared DNA that showed a distinct buoyant density, detectable as a ‘satellite peak’ in DENSITY GRADIENT CENTRIFUGATION, and that was subsequently identified as large centromeric tandem repeats.When shorter (10–30-bp) tandem repeats were later identified, they came to be known as minisatellites. Finally,with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined. The difference between the terms micro- and minisatellites might not be obvious per se, but it is motivated by the difference in the mutational mechanisms of repeats of just a few nucleotides and of ten or more —Preceding unsigned comment added by 59.167.67.245 (talk) 05:05, 18 April 2008 (UTC)
