Micromeritics

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Micromeritics is the science and technology of small particles e.g. micrometre size. The knowledge and control of the size of particles is of importance in pharmacy and materials science.The size & hence the surface area of a particle can be related to the physical, chemical & pharmacologic properties of drugs. Clinically, the particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally & topically. The successful formulation of suspensions, emulsions & tablets; both physical stability & pharmacologic response also depends on the particle size achieved in the product.

Contents

[edit] Applications

[edit] Release & dissolution

Particle size & surface area influence the release of a drug from a dosage form that is administered orally, rectally parenterally & topically. Higher surface area brings about intimate contact of the drug with the dissolution fluids in vivo & increases the drug solubility & dissolution.

[edit] Absorption & drug action

Particle size & surface area influence the drug absorption & subsequently the therapeutic action. Higher the dissolution, faster the absorption & hence quicker & greater the drug action.

[edit] Physical stability

Micromeritc properties of a particle i.e the particle size in a formulation influences the physical stability of the suspensions & emulsions. Smaller the size of the particle, better the physical stability of the dosage form owing to the brownian movement of the particles in the dispersion.

[edit] Dose uniformity

Good flow properties of granules & powders are important in the manufacturing of tablets & capsules. The distribution of particles should be uniform in terms of number & weight.

[edit] External links

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