MIB2 (gene)

From Wikipedia, the free encyclopedia

Mindbomb homolog 2 (Drosophila)

Identifiers

MIB2; FLJ20648; FLJ39787; ZZANK1; ZZZ5

External IDs

Gene ontology
Molecular Function:	• actin binding • ubiquitin-protein ligase activity • signal transducer activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• ubiquitin ligase complex • early endosome
Biological Process:	• Notch signaling pathway • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB cascade

Orthologs

Human

Mouse

Refseq

XM_001125956 (mRNA)
XP_001125956 (protein)

NM_145124 (mRNA)
NP_660106 (protein)

Location

Chr 1: 1.54 - 1.56 Mb

Chr 4: 154.5 - 154.51 Mb

Pubmed search

[1]

[2]

Mindbomb homolog 2 (Drosophila), also known as MIB2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila).

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307-18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.". Am. J. Pathol. 163 (4): 1395-404. PMID 14507647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand.". J. Biol. Chem. 280 (23): 22335-42. doi:10.1074/jbc.M501631200. PMID 15824097.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma.". DNA Cell Biol. 24 (5): 339-44. doi:10.1089/dna.2005.24.339. PMID 15869411.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma.". Am. J. Pathol. 166 (6): 1817-26. PMID 15920166.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion.". Oncogene 25 (53): 7059-69. doi:10.1038/sj.onc.1209688. PMID 16715130.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.