Mezlocillin

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Mezlocillin
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl- 2-oxo-imidazolidine-1-carbonyl)amino]-2-phenyl-acetyl] amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid
Identifiers
CAS number	51481-65-3
ATC code	J01CA10
PubChem	656511
DrugBank	APRD01113
Chemical data
Formula	C21H25N5O8S2
Mol. mass	539.584 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	16–59%
Metabolism	Hepatic (20–30%)
Half life	1.3–4.4 hours
Excretion	Renal (50%) and biliary
Therapeutic considerations
Pregnancy cat.	B
Legal status
Routes	Intravenous, intramuscular

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria.

Contents 1 Mechanism of action 2 Susceptible organisms 2.1 Gram-negative 2.2 Gram-positive 3 External links

[edit] Mechanism of action

Main article: Beta-lactam antibiotic

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

[edit] Susceptible organisms

[edit] Gram-negative

• Bacteroides spp., including B. fragilis
• Enterobacter spp.
• Escherichia coli
• Haemophilus influenzae
• Klebsiella species
• Morganella morganii
• Neisseria gonorrhoeae
• Proteus mirabilis
• Proteus vulgaris
• Providencia rettgeri
• Pseudomonas spp., including P. aeruginosa
• Serratia marcescens

[edit] Gram-positive

• Enterococcus faecalis
• Peptococcus spp.
• Peptostreptococcus spp.

[edit] External links

• DDB 30377
• -288358398 at GPnotebook
• Duke
• Kristof R, Clusmann H, Koehler W, Fink K, Schramm J (1998). "Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange.". J Neurol Neurosurg Psychiatry 64 (3): 379–81. PMID 9527154. 
• McCormick P, Greenslade L, Kibbler C, Chin J, Burroughs A, McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic patients.". Hepatology 25 (4): 833–6. doi:10.1002/hep.510250408. PMID 9096584. 
• Rohde B, Werner U, Hickstein H, Ehmcke H, Drewelow B (1997). "Pharmacokinetics of mezlocillin and sulbactam under continuous veno-venous hemodialysis (CVVHD) in intensive care patients with acute renal failure.". Eur J Clin Pharmacol 53 (2): 111–5. doi:10.1007/s002280050347. PMID 9403281. 

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