Methylquercetagetin 6-O-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a methylquercetagetin 6-O-methyltransferase (EC 2.1.1.84) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone $\rightleftharpoons$ S-adenosyl-L-homocysteine + 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone

Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,6,3',4'-tetrahydroxy-3,7-dimethoxyflavone, whereas its two products are S-adenosylhomocysteine and 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase. Other names in common use include flavonol 6-O-methyltransferase, flavonol 6-methyltransferase, 6-OMT, S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone, and 6-O-methyltransferase.

[edit] References

IUBMB entry for 2.1.1.84
BRENDA references for 2.1.1.84 (Recommended.)
PubMed references for 2.1.1.84
PubMed Central references for 2.1.1.84
Google Scholar references for 2.1.1.84
De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases". Arch. Biochem. Biophys. 238: 596–605. doi:10.1016/0003-9861(85)90205-X. PMID 3994393.
De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases". Arch. Biochem. Biophys. 238: 606–18. doi:10.1016/0003-9861(85)90206-1. PMID 3994394.