Methylarsonate reductase

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In enzymology, a methylarsonate reductase (EC 1.20.4.2) is an enzyme that catalyzes the chemical reaction

methylarsonate + 2 glutathione methylarsonite + glutathione disulfide + H₂O

Thus, the two substrates of this enzyme are methylarsonate and glutathione, whereas its 3 products are methylarsonite, glutathione disulfide, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with disulfide as acceptor. The systematic name of this enzyme class is gluthathione:methylarsonate oxidoreductase. This enzyme is also called MMA(V) reductase.

[edit] References

• IUBMB entry for 1.20.4.2
• BRENDA references for 1.20.4.2 (Recommended.)
• PubMed references for 1.20.4.2
• PubMed Central references for 1.20.4.2
• Google Scholar references for 1.20.4.2
• Zakharyan RA, Aposhian HV (1999). "Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase". Chem. Res. Toxicol. 12: 1278–83. doi:10.1021/tx9901231. PMID 10604879. 

[edit] External links

• IUBMB entry for 1.20.4.2

• KEGG entry for 1.20.4.2

• BRENDA entry for 1.20.4.2

• NiceZyme view of 1.20.4.2

• EC2PDB: PDB structures for 1.20.4.2

• PRIAM entry for 1.20.4.2

• PUMA2 entry for 1.20.4.2

• IntEnz: Integrated Enzyme entry for 1.20.4.2

• MetaCyc entry for 1.20.4.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050610: methylarsonate reductase

• AMIGO entry for GO code 0050610: methylarsonate reductase