Methoxy arachidonyl fluorophosphonate
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| Methoxy arachidonyl fluorophosphonate | |
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| IUPAC name | methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-
tetraenylphosphonofluoridate |
| Other names | MAFP |
| Properties | |
| Molecular formula | C21H36FO2P |
| Molar mass | 370.5 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.
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