Methanosarcina-phenazine hydrogenase

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In enzymology, a Methanosarcina-phenazine hydrogenase (EC 1.12.98.3) is an enzyme that catalyzes the chemical reaction

H₂ + 2-(2,3-dihydropentaprenyloxy)phenazine $\rightleftharpoons$ 2-dihydropentaprenyloxyphenazine

Thus, the two substrates of this enzyme are H₂ and 2-(2,3-dihydropentaprenyloxy)phenazine, whereas its product is 2-dihydropentaprenyloxyphenazine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase. Other names in common use include methanophenazine hydrogenase, and methylviologen-reducing hydrogenase.

[edit] References

IUBMB entry for 1.12.98.3
BRENDA references for 1.12.98.3 (Recommended.)
PubMed references for 1.12.98.3
PubMed Central references for 1.12.98.3
Google Scholar references for 1.12.98.3
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U (1998). "Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1". J. Bacteriol. 180: 2027–32. PMID 9555882.
Deppenmeier U, Lienard T, Gottschalk G (1999). "Novel reactions involved in energy conservation by methanogenic archaea". FEBS. Lett. 457: 291–7. doi:10.1016/S0014-5793(99)01026-1. PMID 10471795.
Beifuss U, Tietze M, Baumer S, Deppenmeier U (2000). "Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals". Angew. Chem. Int. Ed. Engl. 39: 2470–2472. PMID 10941105.