Methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction

methanol + 5-hydroxybenzimidazolylcobamide Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H₂O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H₂O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.

[edit] References

• IUBMB entry for 2.1.1.90
• BRENDA references for 2.1.1.90 (Recommended.)
• PubMed references for 2.1.1.90
• PubMed Central references for 2.1.1.90
• Google Scholar references for 2.1.1.90
• Vogels GD (1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". J. Bacteriol. 160: 629–35. PMID 6438059. 

[edit] External links

The CAS registry number for this enzyme class is 86611-98-5.

• IUBMB entry for 2.1.1.90

• KEGG entry for 2.1.1.90

• BRENDA entry for 2.1.1.90

• NiceZyme view of 2.1.1.90

• EC2PDB: PDB structures for 2.1.1.90

• PRIAM entry for 2.1.1.90

• PUMA2 entry for 2.1.1.90

• IntEnz: Integrated Enzyme entry for 2.1.1.90

• MetaCyc entry for 2.1.1.90

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047152: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase

• AMIGO entry for GO code 0047152: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase