METTL3

From Wikipedia, the free encyclopedia

Methyltransferase like 3

Identifiers

METTL3; M6A; MGC4336; MT-A70; Spo8

External IDs

MGI: 1927165 HomoloGene: 10501

Gene ontology
Molecular Function:	• RNA binding • methyltransferase activity • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• RNA methylation • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019852 (mRNA)
NP_062826 (protein)

NM_019721 (mRNA)
NP_062695 (protein)

Location

Chr 14: 21.04 - 21.05 Mb

Chr 14: 51.22 - 51.23 Mb

Pubmed search

[1]

[2]

Methyltransferase like 3, also known as METTL3, is a human gene.^[1]

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.^[1]

[edit] References

^ ^a ^b Entrez Gene: METTL3 methyltransferase like 3.

[edit] Further reading

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601-7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase.". J. Mol. Evol. 55 (4): 431-44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells.". Int. J. Biochem. Cell Biol. 33 (10): 984-99. PMID 11470232.
Bokar JA, Shambaugh ME, Polayes D, et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.". RNA 3 (11): 1233-47. PMID 9409616.