MERTK

From Wikipedia, the free encyclopedia

C-mer proto-oncogene tyrosine kinase

PDB rendering based on 2dbj.

Available structures: 2dbj, 2p0c

Identifiers

Symbol(s)

MERTK; MER; MGC133349; c-mer

External IDs

OMIM: 604705 MGI: 96965 HomoloGene: 4626

Gene ontology
Molecular Function:	• nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor activity • ATP binding • transferase activity
Cellular Component:	• soluble fraction • integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • cell surface receptor linked signal transduction • cell-cell signaling • visual perception • response to stimulus

Orthologs

Human

Mouse

Refseq

NM_006343 (mRNA)
NP_006334 (protein)

XM_001003774 (mRNA)
XP_001003774 (protein)

Location

Chr 2: 112.37 - 112.5 Mb

Chr 2: 128.39 - 128.49 Mb

Pubmed search

[1]

[2]

C-mer proto-oncogene tyrosine kinase, also known as MERTK, is a human gene.^[1]

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).^[1]

[edit] References

^ ^a ^b Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase.

[edit] Further reading

Iwase T, Tanaka M, Suzuki M, et al. (1993). "Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.". Biochem. Biophys. Res. Commun. 194 (2): 698–705. doi:10.1006/bbrc.1993.1878. PMID 7688222.
Graham DK, Dawson TL, Mullaney DL, et al. (1994). "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer.". Cell Growth Differ. 5 (6): 647–57. PMID 8086340.
Mark MR, Chen J, Hammonds RG, et al. (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.". J. Biol. Chem. 271 (16): 9785–9. PMID 8621659.
Ling L, Templeton D, Kung HJ (1996). "Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase.". J. Biol. Chem. 271 (31): 18355–62. PMID 8702477.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Nagata K, Ohashi K, Nakano T, et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.". J. Biol. Chem. 271 (47): 30022–7. PMID 8939948.
Georgescu MM, Kirsch KH, Shishido T, et al. (1999). "Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.". Mol. Cell. Biol. 19 (2): 1171–81. PMID 9891051.
Weier HU, Fung J, Lersch RA (1999). "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization.". Cytogenet. Cell Genet. 84 (1-2): 91–2. PMID 10343112.
Gal A, Li Y, Thompson DA, et al. (2000). "Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa.". Nat. Genet. 26 (3): 270–1. doi:10.1038/81555. PMID 11062461.
Thompson DA, McHenry CL, Li Y, et al. (2002). "Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively.". Am. J. Hum. Genet. 70 (1): 224–9. PMID 11727200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yin JL, Hambly BD, Bao SS, et al. (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts.". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229.
McHenry CL, Liu Y, Feng W, et al. (2004). "MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells.". Invest. Ophthalmol. Vis. Sci. 45 (5): 1456–63. PMID 15111602.
Chen C, Li Q, Darrow AL, et al. (2004). "Mer receptor tyrosine kinase signaling participates in platelet function.". Arterioscler. Thromb. Vasc. Biol. 24 (6): 1118–23. doi:10.1161/01.ATV.0000130662.30537.08. PMID 15130911.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Li Y, Mahajan NP, Webster-Cyriaque J, et al. (2004). "The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1.". J. Virol. 78 (21): 11778–85. doi:10.1128/JVI.78.21.11778-11785.2004. PMID 15479819.
Gould WR, Baxi SM, Schroeder R, et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Graham DK, Salzberg DB, Kurtzberg J, et al. (2006). "Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.". Clin. Cancer Res. 12 (9): 2662–9. doi:10.1158/1078-0432.CCR-05-2208. PMID 16675557.
Tada A, Wada Y, Sato H, et al. (2006). "Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa.". Mol. Vis. 12: 441–4. PMID 16710167.