MEPE

From Wikipedia, the free encyclopedia

Matrix, extracellular phosphoglycoprotein with ASARM motif (bone)

Identifiers

MEPE; OF45

External IDs

OMIM: 605912 MGI: 2137384 HomoloGene: 10623

Gene ontology
Molecular Function:	• extracellular matrix structural constituent
Cellular Component:	• proteinaceous extracellular matrix
Biological Process:	• skeletal development • negative regulation of bone mineralization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020203 (mRNA)
NP_064588 (protein)

NM_053172 (mRNA)
NP_444402 (protein)

Location

Chr 4: 88.96 - 88.99 Mb

Chr 5: 104.57 - 104.58 Mb

Pubmed search

[1]

[2]

Matrix, extracellular phosphoglycoprotein with ASARM motif (bone), also known as MEPE, is a human gene.^[1]

[edit] References

^ Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone).

[edit] Further reading

Quarles LD (2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.". Am. J. Physiol. Endocrinol. Metab. 285 (1): E1-9. doi:10.1152/ajpendo.00016.2003. PMID 12791601.
Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs).". Kidney Int. 68 (1): 155-66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands.". J. Dent. Res. 83 (9): 664-70. PMID 15329369.
Jain A, Fedarko NS, Collins MT, et al. (2004). "Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density.". J. Clin. Endocrinol. Metab. 89 (8): 4158-61. doi:10.1210/jc.2003-032031. PMID 15292364.
Nampei A, Hashimoto J, Hayashida K, et al. (2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone.". J. Bone Miner. Metab. 22 (3): 176-84. doi:10.1007/s00774-003-0468-9. PMID 15108058.
MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.". Connect. Tissue Res. 43 (2-3): 320-30. PMID 12489176.
Argiro L, Desbarats M, Glorieux FH, Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone.". Genomics 74 (3): 342-51. doi:10.1006/geno.2001.6553. PMID 11414762.
Rowe PS, de Zoysa PA, Dong R, et al. (2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.". Genomics 67 (1): 54-68. doi:10.1006/geno.2000.6235. PMID 10945470.