Medroxyprogesterone

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Medroxyprogesterone
Systematic (IUPAC) name
17-acetyl-17-hydroxy- 6,10,13-trimethyl- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one
Identifiers
CAS number	520-85-4
ATC code	G03AC06 G03DA02, L02AB02
PubChem	10631
DrugBank	APRD00627
Chemical data
Formula	C22H32O3
Mol. mass	344.488 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	?
Half life	50 days
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Medroxyprogesterone is a progestin, and is commonly a component of hormonal contraceptives. It can be used in the treatment of endometriosis, abnormal menstrual bleeding or amenorrhea.^[1][2] Possible side effects include weight gain, depression, and irregular menses or amenorrhea.

Progestins lower the risk of estrogen-related cancer of the uterus. This medicine used in compination with estrogen (hormone replacement therapy - HRT) should not be used to prevent heart disease. Two drug combination HRT (estrogen and progestin menopause) can infrequently cause cancer of the breast, heart disease (e.g., heart attack), stroke, dementia, or blood clots in the lung (pulmonary embolism) or leg. Estrogens may also increase the risk of cancer of the ovary. These risks appear to depend on the length of time this combination is used and the amount of estrogen per dose. Therefore, two-drug HRT should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious side effectis from long-term treatment. If you use this drug for an extended period, you should be evaluated at least once a year.

You should not use this medicine during the first 4 months of pregnancy because birth defects may occur. This medicine has not been proven to prevent natural abortions that occur early in the pregnancy. Often, the cause of an early natural abortion is due to a defective female egg. Using this drug does not fix a defective egg and may get in the way of expelling it.

[edit] References

[edit] See also

• Progestin
• Depo Provera
• Medroxyprogesterone acetate treatment

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS Progestogens: (receptor) PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone Androgens: (receptor) TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone Estrogens: (receptor) ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole Gonadotropins: (FSHR/LHCGR) ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone GnRH: (receptor) agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix