MED28

From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)

Identifiers

MED28; 1500003D12Rik; DKFZP434N185; EG1; magicin

External IDs

OMIM: 610311 MGI: 1914249 HomoloGene: 11873

Gene ontology
Molecular Function:	• actin binding • protein binding
Cellular Component:	• nucleus • cytoskeleton • membrane
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025205 (mRNA)
NP_079481 (protein)

NM_025895 (mRNA)
NP_080171 (protein)

Location

Chr 4: 17.23 - 17.24 Mb

Chr 5: 45.81 - 45.82 Mb

Pubmed search

[1]

[2]

Mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae), also known as MED28, is a human gene.^[1]

[edit] References

^ Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae).

[edit] Further reading

Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653.
Liu C, Zhang L, Shao ZM, et al. (2002). "Identification of a novel endothelial-derived gene EG-1.". Biochem. Biophys. Res. Commun. 290 (1): 602-12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123-7. doi:10.1074/jbc.C300054200. PMID 12584197.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846-51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685-91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Wiederhold T, Lee MF, James M, et al. (2005). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.". Oncogene 23 (54): 8815-25. doi:10.1038/sj.onc.1208110. PMID 15467741.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lu M, Zhang L, Maul RS, et al. (2005). "The novel gene EG-1 stimulates cellular proliferation.". Cancer Res. 65 (14): 6159-66. doi:10.1158/0008-5472.CAN-04-4016. PMID 16024617.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lee MF, Beauchamp RL, Beyer KS, et al. (2006). "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.". Biochem. Biophys. Res. Commun. 348 (3): 826-31. doi:10.1016/j.bbrc.2006.07.126. PMID 16899217.
Lu M, Zhang L, Sartippour MR, et al. (2006). "EG-1 interacts with c-Src and activates its signaling pathway.". Int. J. Oncol. 29 (4): 1013-8. PMID 16964398.
Beyer KS, Beauchamp RL, Lee MF, et al. (2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation.". J. Biol. Chem. 282 (44): 32152-7. doi:10.1074/jbc.M706592200. PMID 17848560.