MED22

From Wikipedia, the free encyclopedia

Surfeit 5

Identifiers

SURF5; MED22; MED24; MGC48682

External IDs

OMIM: 185641 MGI: 98446 HomoloGene: 4913

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• mediator complex • soluble fraction • cytoplasm
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_133640 (mRNA)
NP_598395 (protein)

NM_001033908 (mRNA)
NP_001029080 (protein)

Location

Chr 9: 135.19 - 135.2 Mb

Chr 2: 26.73 - 26.73 Mb

Pubmed search

[1]

[2]

Surfeit 5, also known as SURF5, is a human gene.^[1]

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SURF5 surfeit 5.

[edit] Further reading

De Falco S, Russo G, Angiolillo A, Pietropaolo C (1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene.". Gene 126 (2): 227-35. PMID 8482538.
Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.". Hum. Mol. Genet. 2 (3): 237-40. PMID 8499913.
Garson K, Duhig T, Armes N, et al. (1996). "Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene.". Genomics 30 (2): 163-70. doi:10.1006/geno.1995.9889. PMID 8586415.
Garson K, Duhig T, Fried M (1997). "Tissue-specific processing of the Surf-5 and Surf-4 mRNAs.". Gene Expr. 6 (4): 209-18. PMID 9196076.
Duhig T, Ruhrberg C, Mor O, Fried M (1999). "The human Surfeit locus.". Genomics 52 (1): 72-8. doi:10.1006/geno.1998.5372. PMID 9740673.
Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.". Gene 284 (1-2): 169-78. PMID 11891058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123-7. doi:10.1074/jbc.C300054200. PMID 12584197.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671-4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846-51. doi:10.1074/jbc.M312523200. PMID 14638676.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685-91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.